The Zhu Lab

Research

Our lab focuses on mechanobiology at the cellular and molecular level, with special interest on single molecular adhesion.

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2023

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Mechanical force regulates ligand binding and function of PD-1
Kaitao Li, Paul Cardenas-Lizana, Anna V. Kellner, Zhou Yuan, Eunseon Ahn, Jintian Lyu, Zhenhai Li, Khalid Salaita, Rafi Ahmed, Cheng Zhu
bioRxiv  ·  15 Aug 2023
Immuno-mechanobiology
Preprint
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Mechanotransduction governs CD40 function and underlies X-linked Hyper IgM syndrome
Hyun-Kyu Choi, Stefano Travaglino, Matthias Münchhalfen, Richard Görg, Zhe Zhong, Jintian Lyu, David M. Reyes-Aguilar, Jürgen Wienands, Ankur Singh, Cheng Zhu
bioRxiv  ·  25 Jul 2023
Immuno-mechanobiology
Preprint
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Catch bond models may explain how force amplifies TCR signaling and antigen discrimination
Hyun-Kyu Choi, Peiwen Cong, Chenghao Ge, Aswin Natarajan, Baoyu Liu, Yong Zhang, Kaitao Li, Muaz Nik Rushdi, Wei Chen, Jizhong Lou, Michelle Krogsgaard, Cheng Zhu
Nature Communications  ·  05 May 2023
Immuno-mechanobiology
Source
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Force-regulated spontaneous conformational changes of integrins α5β1 and αVβ3
Yunfeng Chen, Fang Kong, Zhenhai Li, Lining Arnold Ju, Cheng Zhu
bioRxiv  ·  09 Jan 2023
Platelet mechanobiology
Preprint

2022

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Catch bond models may explain how force amplifies TCR signaling and antigen discrimination
Hyun-Kyu Choi, Peiwen Cong, Chenghao Ge, Aswin Natarajan, Baoyu Liu, Yong Zhang, Kaitao Li, Muaz Nik Rushdi, Wei Chen, Jizhong Lou, Michelle Krogsgaard, Cheng Zhu
bioRxiv  ·  24 Dec 2022
Immuno-mechanobiology
Preprint
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Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity
Muaz Nik Rushdi, Victor Pan, Kaitao Li, Hyun-Kyu Choi, Stefano Travaglino, Jinsung Hong, Fletcher Griffitts, Pragati Agnihotri, Roy A. Mariuzza, Yonggang Ke, Cheng Zhu
Nature Communications  ·  17 Nov 2022
Immuno-mechanobiology
Source
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Signaling mechanisms of the platelet glycoprotein Ib-IX complex
Yaping Zhang, Samuel M Ehrlich, Cheng Zhu, Xiaoping Du
Platelets  ·  18 Aug 2022
Platelet mechanobiology
Source
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Cooperative ectodomain interaction among TCRαβ, CD3γε, and CD3δε enhances TCR mechanotransduction
Zhou Yuan, Peiwen Cong, Aswin Natarajan, Chenghao Ge, Stefano Travaglino, Saikiran Beesam, Danielle Grazette, Michelle Krogsgaard, Cheng Zhu
bioRxiv  ·  15 Apr 2022
Immuno-mechanobiology
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Immuno-mechanobiology
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