Research | The Zhu Lab

Mechanical force regulates ligand binding and function of PD-1

Kaitao Li, Paul Cardenas-Lizana, Anna V. Kellner, Zhou Yuan, Eunseon Ahn, Jintian Lyu, Zhenhai Li, Khalid Salaita, Rafi Ahmed, Cheng Zhu

bioRxiv · 15 Aug 2023

Immuno-mechanobiology

Preprint

Mechanotransduction governs CD40 function and underlies X-linked Hyper IgM syndrome

Hyun-Kyu Choi, Stefano Travaglino, Matthias Münchhalfen, Richard Görg, Zhe Zhong, Jintian Lyu, David M. Reyes-Aguilar, Jürgen Wienands, Ankur Singh, Cheng Zhu

bioRxiv · 25 Jul 2023

Immuno-mechanobiology

Preprint

Catch bond models may explain how force amplifies TCR signaling and antigen discrimination

Hyun-Kyu Choi, Peiwen Cong, Chenghao Ge, Aswin Natarajan, Baoyu Liu, Yong Zhang, Kaitao Li, Muaz Nik Rushdi, Wei Chen, Jizhong Lou, Michelle Krogsgaard, Cheng Zhu

Nature Communications · 05 May 2023

Immuno-mechanobiology

Source

Force-regulated spontaneous conformational changes of integrins α5β1 and αVβ3

Yunfeng Chen, Fang Kong, Zhenhai Li, Lining Arnold Ju, Cheng Zhu

bioRxiv · 09 Jan 2023

Platelet mechanobiology

Preprint

Catch bond models may explain how force amplifies TCR signaling and antigen discrimination

Hyun-Kyu Choi, Peiwen Cong, Chenghao Ge, Aswin Natarajan, Baoyu Liu, Yong Zhang, Kaitao Li, Muaz Nik Rushdi, Wei Chen, Jizhong Lou, Michelle Krogsgaard, Cheng Zhu

bioRxiv · 24 Dec 2022

Immuno-mechanobiology

Preprint

Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity

Muaz Nik Rushdi, Victor Pan, Kaitao Li, Hyun-Kyu Choi, Stefano Travaglino, Jinsung Hong, Fletcher Griffitts, Pragati Agnihotri, Roy A. Mariuzza, Yonggang Ke, Cheng Zhu

Nature Communications · 17 Nov 2022

Immuno-mechanobiology

Source